Home Page


What's New






A.Y. Denisov, F.P. McManus, D.K. O'Flaherty, A.M. Noronha, C.J. Wilds "Structural Basis of Interstrand Cross-link Repair by O6-Alkylguanine DNA Alkyltransferase," Org. Biomol. Chem. (2017) online. http://dx.doi.org/10.1039/C7OB02093G

P. Dagenais, N. Girard, E. Bonneau, P. Legault "Insights into RNA structure and dynamics from recent NMR and X-ray studies of the Neurospora Varkud satellite ribozyme," Wiley Interdisciplinary Reviews: RNA (2017) online. http://dx.doi.org/10.1002/wrna.1421


L. Volpon, B. Culjkovic-Kraljacic, M.J. Osborne, A. Ramteke, Q. Sun, A. Niesman, Y.M. Chook, K.L.B. Borden, "Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E," Proc Natl Acad Sci USA 113 (2016) 5263–5268. http://dx.doi.org/10.1073/pnas.1524291113

S.M.C. Gobeil, D. Gagné, N. Doucet, J.N. Pelletier "15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant," Biomolecular NMR Assignments 10 (2016) 93-99. http://dx.doi.org/10.1007/s12104-015-9645-8


A.P. Ramos and M. Lafleur, "The chain length of free fatty acids influences the phase behaviour of stratum corneum model membranes," Langmuir 31 (2015) 11621–11629. http://dx.doi.org/10.1021/acs.langmuir.5b03271

E. Bonneau, N. Girard, S. Lemieux and P. Legault, "The NMR structure of the II–III–VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure," RNA 21 (2015) 1621-1632. http://dx.doi.org/10.1261/rna.052076.115

N. Cyr, C. Fuente, L. Lecoq, I. Guendel, P.R. Chabot, K. Kehn-Hall, and J.G. Omichinski, "A Sigma-XaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence," PNAS 112 (2015) 602-6026. http://dx.doi.org/10.1073/pnas.1503688112


E. Bonneau and P. Legault, "Nuclear Magnetic Resonance Structure of the III–IV–V Three-Way Junction from the Varkud Satellite Ribozyme and Identification of Magnesium-Binding Sites Using Paramagnetic Relaxation Enhancement," Biochemistry 53 (2014) 6264-6275. http://dx.doi.org/10.1021/bi500826n

T. Dieckmann, M. Piazza, E. Bonneau, P. Legault, "Biomolecular NMR Spectroscopy of Ribonucleic Acids," eLS (2014) online. (review) http://dx.doi.org/10.1002/9780470015902.a0021033.pub2

P.R. Chabot, L. Raiola, M. Lussier-Price, T. Morse, G. Arseneault, J. Archambault, J.G. Omichinski, "Structural and Functional Characterization of a Complex between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 Subunit of TFIIH," PLoS Pathogenes 10 (2014) e1004042. http://dx.doi.org/10.1371/journal.ppat.1004042

E. Bonneau and P. Legault, "NMR Localization of Divalent Cations at the Active Site of the Neurospora VS Ribozyme Provides Insights Into RNA-Metal Ion Interactions," Biochemistry 53 (2014) 579–590. http://dx.doi.org/10.1021/bi401484a

P. Bouchard and P. Legault, "Structural insights into substrate recognition by the Neurospora VS ribozyme: importance of U-turns at the kissing-loop junction," Biochemistry 53 (2014) 258–269. http://dx.doi.org/10.1021/bi401491g


X.H. Mascle, M. Lussier-Price, L. Cappadocia, P. Estephan, L. Raiola, J.G. Omichinski and M. Aubry, "Identification of a Non-covalent Ternary Complex Formed by PIAS1, SUMO1, and UBC9 Proteins Involved in Transcriptional Regulation," Journal of Biological Chemistry 288 (2013) 36312-36327. http://dx.doi.org/10.1074/jbc.M113.486845

L. Raiola, M. Lussier-Price, D. Gagnon, J. Lafrance-Vanasse, X. Mascle, G. Arseneault, P. Legault, J. Archambault, J.G. Omichinski, "Structural Characterization of a Noncovalent Complex between Ubiquitin and the Transactivation Domain of the Erythroid-Specific Factor EKLF," Structure 21 (2013) 2014–2024. http://dx.doi.org/10.1016/j.str.2013.08.027

L. Volpon, M.J. Osborne, H. Zahreddine, A.A. Romeo, K.L.B. Borden, "Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate," Biochemical and Biophysical Research Communications 434 (2013) 614–619. http://dx.doi.org/10.1016/j.bbrc.2013.03.125

N. Goudreau, R. Coulombe, A.-M. Faucher, C. Grand-Maitre, J.-E. Lacoste, C.T. Lemke, E. Malenfant, Y. Bousquet, L. Fader, B. Simoneau, J.-F. Mercier, S. Titolo, and S.W. Mason, "Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using 19F Ligand-and 15N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series," ChemMedChem 8 (2013) 405–414. (Cover Article) http://dx.doi.org/10.1002/cmdc.201200580

J. Lafrance-Vanasse, G. Arseneault, L. Cappadocia, P. Legault and J.G. Omichinski, "Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER," Nucleic Acids Research 41 (2013) 2736-2745. http://dx.doi.org/10.1093/nar/gks1321

A.A. Arnold, F. Byette, M.-O. Séguin-Heine, A. LeBlanc, L. Sleno, R. Tremblay, C. Pellerin, and I. Marcotte, "Solid-state NMR structure determination of whole anchoring threads from the blue mussel Mytilus edulis," Biomacromolecules 14 (2013) 132–141. http://dx.doi.org/10.1021/bm301493u


P. Dagenais, P. Legault, "Preparative separation of ribonucleoside monophosphates by ion-pair reverse-phase HPLC," Methods in molecular biology 941 (2012) 247-256. http://dx.doi.org/10.1007/978-1-62703-113-4_18

C.M. Clouthier, S. Morin, S.M.C. Gobeil, N. Doucet, J. Blanchet, E. Nguyen, S.M. Gagné, J.N. Pelletier, "Chimeric beta-Lactamases: Global Conservation of Parental Function and Fast Time-Scale Dynamics with Increased Slow Motions," PLoS ONE 7 (2012) e52283. http://dx.doi.org/10.1371/journal.pone.0052283

Z.-K. Cui, A. Bouisse, N. Cottenye, M. Lafleur, "Formation of pH-sensitive cationic liposomes from a binary mixture of monoalkylated primary amine and cholesterol," Langmuir 28 (2012) 13668–13674. http://dx.doi.org/10.1021/la302278q

B. Culjkovic-Kraljacic, A. Baguet, L. Volpon, A. Amri and K.L.B. Borden, "The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation," Cell Reports 2 (2012) 207–215. http://dx.doi.org/10.1016/j.celrep.2012.07.007

J. Lafrance-Vanasse, G. Arseneault, L. Cappadocia, H.-T. Chen, L. Pascale, J.G. Omichinski, "Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2," Nucleic Acids Research 40 (2012) 5739-5750. http://dx.doi.org/10.1093/nar/gks194

J. Agullo, S. Canesi, F. Schaper, M. Morin, and D. Belanger, "Formation and Reactivity of 3-Diazopyridinium Cations and Influence on Their Reductive Electrografting on Glassy Carbon," Langmuir 28 (2012) 4889-4895. http://dx.doi.org/10.1021/la2048757

S. Kwak, E. Brief, D. Langlais, N. Kitson, M. Lafleur, J. Thewalt, "Ethanol perturbs lipid organization in models of stratum corneum membranes: An investigation combining differential scanning calorimetry, infrared and 2H NMR spectroscopy," Biochimica et Biophysica Acta (BBA) - Biomembranes 1818 (2012) 1410–1419. http://dx.doi.org/10.1016/j.bbamem.2012.02.013

C. Langlois, A. Del Gatto, G. Arseneault, J. Lafrance-Vanasse, M. De Simone, T. Morse, I. de Paola, M. Lussier-Price, P. Legault, C. Pedone, L. Zaccaro, and J.G. Omichinski, "Structure-Based Design of a Potent Artificial Transactivation Domain Based on p53," J. Am. Chem. Soc. 134 (2012) 1715–1723. http://dx.doi.org/10.1021/ja208999e


M.-A. Gagnon, M. Lafleur, "Comparison between nuclear magnetic resonance profiling and the source/sink approach for characterizing drug diffusion in hydrogel matrices," Pharmaceutical Development and Technology 16 (2011) 651-656. http://dx.doi.org/10.3109/10837450.2010.502900

NMR Spectroscopy of Polymers H. Thérien-Aubin, Y.J. Wang, and X.X. Zhu, "NMR Imaging and Its Application in the Study of Pharmaceutical Tablets," Chapter 27, NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules, Eds. H.N. Cheng, T. Asakura, A.D. English, ACS (2011) pp. 441-457. http://dx.doi.org/10.1021/bk-2011-1077.ch027

Y.J. Wang, E. Assaad, P. Ispas-Szabo, M.A. Mateescu, X.X. Zhu, "NMR imaging of chitosan and carboxymethyl starch tablets: Swelling and hydration of the polyelectrolyte complex," International Journal of Pharmaceutics 419 (2011) 215-221. http://dx.doi.org/10.1016/j.ijpharm.2011.08.008

G. Desjardins, E. Bonneau, N. Girard, J. Boisbouvier, P. Legault, "NMR structure of the A730 loop of the Neurospora VS ribozyme: insights into the formation of the active site," Nucleic Acids Research 39 (2011) 4427-4437. http://dx.doi.org/10.1093/nar/gkq1244

C. Mas, M. Lussier-Price, S. Soni, T. Morse, G. Arseneault, P. Di Lello, J. Lafrance-Vanasse, J.J. Bieker, and J.G. Omichinski, "Structural and functional characterization of an atypical activation domain in erythroid Krüppel-like factor (EKLF)," Proc. Natl. Acad. Sci. USA 108 (2011) 10484-10489. http://dx.doi.org/10.1073/pnas.1017029108

M.-A. Gagnon, M. Lafleur, "Comparison of the structure and the transport properties of low-set and high-set curdlan hydrogels," Journal of Colloid and Interface Science 357 (2011) 419-427. http://dx.doi.org/10.1016/j.jcis.2011.02.033

G.D. Tomasso, P. Lampron, P. Dagenais, J.G. Omichinski, P. Legault, "The ARiBo tag: a reliable tool for affinity purification of RNAs under native conditions," Nucleic Acids Research 39 (2011) e18. http://dx.doi.org/10.1093/nar/gkq1084


Z.-K. Cui, G. Bastiat, M. Lafleur, "Formation of Fluid Lamellar Phase and Large Unilamellar Vesicles with Octadecyl Methyl Sulfoxide/Cholesterol Mixtures," Langmuir 26 (2010) 12733-12739. http://dx.doi.org/10.1021/la100749k

S. Morin, C.M. Clouthier, S. Gobeil, J.N. Pelletier and S.M. Gagné, "Backbone resonance assignments of an artificially engineered TEM-1/PSE-4 Class A ß-lactamase chimera," Biomolecular NMR Assignments 4
(2010) 127-130. http://dx.doi.org/10.1007/s12104-010-9227-8

Y.J. Wang, H. Therien-Aubin, W.E. Baille, J.T. Luo, X.X. Zhu, "Effect of molecular architecture on the self-diffusion of polymers in aqueous systems: A comparison of linear, star, and dendritic poly(ethylene glycol)s," Polymer 51 (2010) 2345-2350. http://dx.doi.org/10.1016/j.polymer.2010.03.047

V. Delfosse, P. Bouchard, E. Bonneau, P. Dagenais, J.F. Lemay, D.A. Lafontaine, P. Legault, "Riboswitch structure: an internal residue mimicking the purine ligand," Nucleic Acids Research 38 (2010) 2057-2068. http://dx.doi.org/10.1093/nar/gkp1080

Z.-K. Cui, G. Bastiat, C. Jin, A. Keyvanloo, M. Lafleur, "Influence of the nature of the sterol on the behavior of palmitic acid/sterol mixtures and their derived liposomes," Biochimica et Biophysica Acta (BBA) - Biomembranes 1798 (2010) 1144-1152. http://dx.doi.org/10.1016/j.bbamem.2010.02.008

Y.J. Wang, F. Ravenelle, and X.X. Zhu, "NMR imaging study of cross-linked high-amylose starch tablets — The effect of drug loading," Canadian Journal of Chemistry 88 (2010) 202-207. http://dx.doi.org/10.1139/V09-170


M.A. Gagnon, M. Lafleur, "Self-Diffusion and Mutual Diffusion of Small Molecules in High-Set Curdlan Hydrogels Studied by 31P NMR," J. Phys. Chem. B 113 (2009) 9084–9091. http://dx.doi.org/10.1021/jp81105p

E. Brief, S. Kwak, J.T. J. Cheng, N. Kitson, J. Thewalt, and M. Lafleur, "Phase Behavior of an Equimolar Mixture of
N-Palmitoyl-D-erythro-sphingosine, Cholesterol, and Palmitic Acid,
a Mixture with Optimized Hydrophobic Matching," Langmuir 25 (2009) 7523–7532. http://dx.doi.org/10.1021/la9003643

J.D. Dikeakos, P. Di Lello, M.J. Lacombe, R. Ghirlando, P. Legault, T.L. Reudelhuber, J.G. Omichinski, "Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease," Proceedings of The National Academy of Sciences of The United States of America 106 (2009) 7408-7413. http://dx.doi.org/10.1073/pnas.0809576106

T. Phoeung, L.M. Huber, M. Lafleur, "Cationic Detergent/Sterol Mixtures Can Form Fluid Lamellar Phases and Stable Unilamellar Vesicles," Langmuir 25 (2009) 5778-5784. http://dx.doi.org/10.1021/la804222w

Y. Cao, N. Zhao, K. Wu, X.X. Zhu, "Solution Properties of a Thermosensitive Triblock Copolymer of N-Alkyl Substituted Acrylamides," Langmuir 25 (2009) 1699-1704. http://dx.doi.org/10.1021/la802971s

A. Yang, K.L. Abbott, A. Desjardins, P. Di Lello, J.G. Omichinski and P. Legault, "NMR Structure of a Complex Formed by the Carboxyl-Terminal Domain of Human RAP74 and a Phosphorylated Peptide from the Central Domain of the FCP1 Phosphatase," Biochemistry 48 (2009) 1964-1974. http://dx.doi.org/10.1021/bi801549m

H. Thérien-Aubin, X.X. Zhu, "NMR Spectroscopy and Imaging Studies of Pharmaceutical Tablets Made of Starch," Carbohydrate Polymers 75 (2009) 369-379. http://dx.doi.org/10.1016/j.carbpol.2008.08.010


C. Langlois, C. Mas, P. Di Lello, L.M.M. Jenkins, P. Legault, J.G. Omichinski, "NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16: Structural similarities between VP16 and p53", Journal of The American Chemical Society 130 (2008) 10596-10640. http://dx.doi.org/10.1021/ja800975h

P. Bouchard, J. Lacroix-Labonte, G. Desjardins, P. Lampron, V. Lisi, S. Lemieux, F. Major, P. Legault, "Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme", RNA-A Publication of The RNA Society 14 (2008) 736-748. http://dx.doi.org/10.1261/rna.824308

P. Di Lello, L.M.M. Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J.G. Omichinski, "P53 and TFIIE alpha share a common binding site on the Tfb1/p62 subunit of TFIIH", Proceedings of The National Academy of Sciences of The United States of America 105 (2008) 106-111. http://dx.doi.org/10.1073/pnas.0707892105

H. Thérien-Aubin, W.E. Baille, X.X. Zhu, "Diffusion of molecular probes and the effects of their interactions with polymer matrices as studied by pulsed-field gradient NMR spectroscopy", Canadian Journal of Chemistry 86 (2008) 579-585. http://dx.doi.org/10.1139/V08-036

H. Thérien-Aubin, X.X. Zhu, F. Ravenelle, and R.H. Marchessault, "Membrane Formation and Drug Loading Effects in High Amylose Starch Tablets Studied by NMR Imaging," Biomacromolecules 9 (2008) 1248-1254. http://dx.doi.org/10.1021/bm701256z


H. Thérien-Aubin, X.X. Zhu, C.N. Moorefield, K. Kotta, G. Newkome, “Effect of ionic binding on the self-diffusion of anionic dendrimers and hydrophilic polymers in aqueous systems as studied by pulsed gradient NMR techniques,” Macromolecules 40 (2007) 3644-3649. http://dx.doi.org/10.1021/ma070372t

H. Thérien-Aubin, F. Janvier, W.E. Baille, X.X. Zhu and R.H. Marchessault, "Study of Hydration of Cross-Linked High Amylose Starch by Solid State 13C NMR Spectroscopy," Carbohydrate Research 342 (2007) 1525-1529. http://dx.doi.org/10.1016/j.carres.2007.04.014

J.T. Luo, C. Pardin, W.D. Lubell, X.X. Zhu, "Poly(Vinyl Alcohol)-Graft-Poly(Ethylene Glycol) Resins And Their Use In Solid-Phase Synthesis And Supported TEMPO Catalysis" Chemical Communications 21 (2007) 2136-2138. http://www.rsc.org/Publishing/Journals/CC/article.asp?doi=b700215g